Feline Calicivirus (FCV) is a common infection in cats caused by several strains of calicivirus. It causes flu-like symptoms and more severe disease in some cats.

A particularly virulent strain of FCV – Virulent Systemic Feline Calicivirus (VS-FCV) – emerged in England in 2003. Australia's first outbreak was reported in Sydney in June 2016.

VS-FCV can cause severe generalised diseases through severe vasculitis and ulcerations by epithelial cell cytolysis.

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